Process-Scale Chromatography: Things To Consider For Maximizing Productivity

 Chromatography is a term used to separate ingredients in a mixture. It mainly consists of mobile and stationary phase. When the mixture turns into a liquid body, it is called the mobile stage, which is then transmitted, by arrangement containing another substance for further processing, this is called the stationary stage.

There are several processes for separating the elements in a mixture, among which the distillation column system is the most used process. The elements in the mixture are distributed by distillation column manufacturers, based on their affinity for the two phases. Particles with greater gravity for the stationary phase move relatively slower than the other. Separate particles are then analyzed to known parameters. 

Media: Media do affect column packing: particle size, its uniformity; forms such as liquid or the mobile used to pack the media needs to be considered. Following is an outlook on the list of things to study in the mobile stage to render effectiveness:

  • Check the chemical adaptability of mobile phase with media.
  • Any notable reduction in size or swelling of media in mobile phase needs to be considered while choosing.
  • Thickness, and PH stability of the media
  • Compatibility between the two phases: Mobile & Stationary.
  • Distillation column manufacturers state that one of the best ways to separate elements in a mixture is by not stirring them since it can affect the flow through column making it non-uniform and hard to flow.
  • To achieve the best result, let it the mixture settle gravitationally. The time for completion of the process varies with the elements present in the mix.

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